moclobemide
Brand name Manerix
Used in the following combined preparations None
general information
Moclobemide is the first of a new class of antidepressants known as reversible inhibitors of monoamine oxidase A (RlMA). By relieving depressive illness, rnoclobemide helps elevate mood and restore interest in everyday activities. Like all antidepressants, it takes at least one to two weeks before rnoclobemide starts to lift depression.
Unlike the traditional, non-reversible MAOIs – for example, phenelzine and tranylcypromine – rnoclobemide is not likely to interact with foods that contain tyramine, such as matured cheeses and yeast extracts. However, it is advisable to avoid large quantities of tyramine-rich foods because some people may be particularly sensitive.
Quick reference
Drug group Antidepressant.
Overdose danger rating High
Dependence rating Medium
Prescription needed Yes
Available as generic No
Information for users
Your drug prescription is tailored for you. Do not alter dosage without checking with your doctor.
How taken
Tablets.
Frequency and timing of doses
2-4 x daily.
Adult dosage range
150-600mg daily.
Onset of effect
1-4 weeks.
Duration of action
Up to 24 hours.
Diet advice
Avoid very large amounts of tyramine-rich foods (e.g., matured cheeses, yeast extracts, and fermented soya bean products).
Storage
Keep in a closed container in a cool, dry place out of the reach of children.
Missed dose
Take as soon as you remember. If your next dose is due within 2 hours, take a single dose now and skip the next.
Stopping the drug
Do not stop the drug without consulting your doctor; symptoms may recur.
overdose action
Seek immediate medical advice : in all cases. Take emergency action if muscle stiffness, tremors, or sweating occur.
Possible adverse effects
Moclobemide is generally well tolerated. Adverse effects such as sleep disturbances, nausea, and headache usually disappear after a while.
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Symptom/effect
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Frequency
Common
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Rare
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Discus doctor
Only if severe
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with
In all cases
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Stop taking drug now
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Call
doctor
now
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Sleep disturbances
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•
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■
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Dizziness
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•
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■
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Nausea
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•
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■
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Headache
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•
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■
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Confusion
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•
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■
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Restlessness/agitation
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•
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■
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Interactions
I note
A number of drugs interact with moclobemide. Discuss this with your doctor or pharmacist.
Cimetidine
The levels of moclobemide may be increased by cimetidine, requiring an adjustment in dosage.
Ephedrine, pseudoephedrine, Phenylpropanolamine These drugs should not be taken with moclobemide.
Antidepressant drugs
In some cases, a time lapse may be required when changing from another antidepressant to moclobemide.
Opioid analgesics .
Drugs in this group, such as pethidine, codeine, morphine, and fentanyl, have enhanced effects if taken with moclobemide.
Special precautions
Be sure to tell your doctor if:
▼ You have a long-term liver problem,
▼ You have phaeochromocytoma.
▼ You have an overactive thyroid.
▼ You are taking other medications.
Pregnancy
▼ Safety in pregnancy not established. Discuss with your doctor.
Breast-feeding
Small amounts of the drug pass into the breast milk. Discuss with your doctor.
Infants and children
Not recommended.
Over 60
▼ No special problems.
Driving and hazardous work
▼ Avoid such activities until you have learned how moclobemide affects you because the drug can cause dizziness and confusion.
Alcohol
Avoid excessive amounts.
Surgery and general anaesthetics
▼ Discuss this with your doctor or dentist before any surgery.
prolonged use
No problems expected.
