Fluticasone
Brand names Cutivate, Flixonase, Flixotide
Used in the following combined preparations None
General Information
Fluticasone is a corticosteroid drug used to control asthma and relieve the symptoms of allergic rhinitis. The drug acts mainly by reducing inflammation. Fluticasone does not produce relief immediately, so it is important to take the drug regularly. For allergic rhinitis, treatment with the nasal spray needs to begin two to three weeks before the hay fever season commences. People who suffer from asthma should take fluticasone regularly by inhaler in order to prevent attacks. Proper instruction is essential to ensure that the inhaler is used correctly. Fluticasone is also prescribed in the form of an ointment or cream to treat dermatitis and eczema (see Topical corticosteroids).
There are few serious adverse effects associated with fluticasone because it is administered directly into the lungs (by the inhaler) or nasal mucosa (by the nasal spray). Fungal infection causing irritation of the mouth and throat is a possible side effect of the inhaled form but can be minimized by thoroughly rinsing the mouth and gargling with water after each inhalation.
Information for Users
Your drug prescription is tailored for you. Do not alter dosage without checking with your doctor.
How taken
Ointment, cream, inhaler, nasal spray.
Frequency and timing of doses
Allergic rhinitis 1-2 x daily; asthma 2 x daily.
Adult dosage range
Allergic rhinitis 2 sprays into each nostril per dose; asthma 100-1,000mcg per dose.
Onset of effect
4-7 days (asthma); 3-4 days (allergic rhinitis). Duration of action
The effects can last for several days after stopping the drug.
Diet advice
None.
Storage
Keep in a cool, dry place out of the reach of children.
Missed dose
Take as soon as you remember. Stopping the drug
Do not stop the drug without consulting your doctor; symptoms may recur.
Exceeding the dose
An occasional unintentional extra dose is unlikely to be a cause for concern. Adverse effects may occur if the recommended dose is regularly exceeded over a prolonged period.
Possible Adverse Effects
Adverse effects are unlikely to occur. The main side effects are irritation of the nasal passages (nasal spray) and fungal infection of the throat and mouth (inhaler).
Interactions
None.
Quick Reference
Drug group Corticosteroid
Overdose danger rating Low
Dependence rating Low
Prescription needed Yes
Available as generic No
Special Precautions
Be sure to tell your doctor if:
You have chronic sinusitis.
You have had nasal ulcers or surgery.
You have had tuberculosis or another respiratory infection.
You are taking other medications.
Pregnancy
Safety in pregnancy not established. Discuss with your doctor.
Breast-feeding
Safety in breast-feeding not established. However, fluticasone is unlikely to pass into breast milk. Discuss with your doctor.
Infants and children
Not recommended under 4 years. Reduced dose necessary in older children. Avoid prolonged use of ointment in children.
Over 60
No known problems.
Driving and hazardous work
No known problems.
Alcohol
No known problems.
Prolonged Use
No problems expected when used for asthma or rhinitis. Prolonged use of ointment and cream can lead to adrenal suppression and can cause permanent skin changes, particularly in facial skin, and should be avoided whenever possible.
Monitoring Periodic checks to confirm that the adrenal glands are functioning properly may be required if large doses are being taken.
