Advice for non-medical people


by doctorbac


Brand names Dothapax, Prepadine, Prothiaden.

Used in the following combined preparations None

General Information

Dothiepin belongs to the tricyclic class of antidepressant drugs, and is used in the long-term treatment of depression. The drug is particularly useful when the depression is accompanied by anxiety and insomnia. Dothiepin has a number of effects – it elevates mood, increases physical activity, improves appetite, and restores interest in everyday activities.

Information for Users

Your drug prescription is tailored for you. Do not alter dosage without checking with your doctor.

How taken
Tablets, capsules.

Frequency and timing of doses
2-3 x daily or once at night.

Adult dosage range
75-150mg daily.

Onset of effect
Full antidepressant effect may not be felt for 2-4 weeks, but adverse effects may be noticed within a day or two.

Duration of action
Several days.

Diet advice

Taken at night, dothiepin encourages sleep and helps eliminate the need to take additional sleeping drugs.

Dothiepin takes several weeks to achieve its full antidepressant effect. Its adverse effects, which are common to all tricyclic drugs, including a risk of causing dangerous heart rhythms, fits, and coma if it is taken in overdose.

Keep in a closed container in a cool, dry place out of the reach of children.

Missed dose
Take as soon as you remember. If your next dose is due within 2 hours, take a single dose now and skip the next.

Stopping the drug

Do not stop taking the drug without consulting your doctor, who may supervise a gradual reduction in dosage. Abrupt cessation of the drug may cause withdrawal symptoms and a recurrence of the original problem.

Overdose Action

Seek immediate medical advice in all cases. Take emergency action if palpitations or loss of consciousness occur.
See Drug poisoning emergency guide.

Possible Adverse Effects

The adverse effects of this drug are mainly the effects are more common in the early days result of its anticholinergic action. These of treatment.


All drugs that have sedative effects intensify those of dothiepin.

Heavy smoking
This may reduce the antidepressant effect of dothiepin.
Monoamine oxidase inhibitors (MAOIs)

In the rare cases where these drugs are given with dothiepin, serious interactions may occur.

Quick Reference

Drug group Tricyclic antidepressant drug
Overdose danger rating High
Dependence rating Low
Prescription needed Yes
Available as generic Yes

Special Precautions

Be sure to tell your doctor if:

You have heart problems.
You have had epileptic fits,
You have long-term liver or kidney problems.
You have glaucoma,
You have prostate trouble.
You are taking other medications.

Safety in pregnancy not established. Discuss with your doctor.

The drug passes into the breast milk, but effects on the baby are unlikely. Discuss with your doctor.

Infants and children
Not recommended.

Over 60
Reduced dose may be necessary.

Driving and hazardous work
Avoid such activities until you have learned how dothiepin affects you because the drug can reduce alertness and may cause blurred vision, dizziness, and drowsiness.

Avoid. Alcohol may increase the sedative effects of this drug.

Surgery and general anaesthetics
Treatment with dothiepin may need to be stopped before you have a general anaesthetic. Discuss this with your doctor or dentist before any operation.

Prolonged Use

No problems expected.

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