Brand name Megace
Used in the following combined preparations None
General information
Megestrol is a progestogen, which is a synthetic female sex hormone similar to the natural hormone progesterone. The drug is used in the treatment of certain types of advanced cancer affecting the breast and uterus that are sensitive to hormone treatment. Megestrol is often prescribed when the tumour cannot be removed by surgery, when the disease has recurred after surgery, or when treatment with other anticancer drugs or radiotherapy have failed.
Successful treatment with megestrol reduces the size of the tumour; the drug may also cause secondary growths to disappear. Improvement usually occurs within two months of starting treatment. Because megestrol does not eradicate the cancer completely, the drug may need to be continued indefinitely.
Quick reference
Drug group Female sex hormone and anticancer drug.
Overdose danger rating Low
Dependence rating Low
Prescription needed Yes
Available as generic No
Information for users
Your drug prescription is tailored for you. Do not alter dosage without checking with your doctor.
How taken
Tablets.
Frequency and timing of closes
1-4 x daily.
Adult dosage range
Breast cancer 160mg daily. Cancer of the uterus 40-320mg daily.
Onset of effect
Within 2 months.
Duration of action
1-2 days.
Diet advice
None.
Storage
Keep in a closed container in a cool, dry place out of the reach of children.
Missed dose
Take as soon as you remember.
Stopping the drug
Do not stop the drug without consulting your doctor. Stopping the drug may lead to worsening of your underlying condition.
Exceeding the dose
An occasional unintentional extra dose is unlikely to be a cause for concern. But if you notice any unusual symptoms, or if a large overdose has been taken, notify your doctor.
Special precautions
Be sure to tell your doctor if:
You have long-term liver or kidney problems.
You have had thrombosis.
You have high blood pressure.
You have heart problems.
You are taking other medications.
Pregnancy
Not usually prescribed.
Breast-feeding
Breast-feeding is usually discontinued. Discuss with your doctor.
Infants and children
Not usually required.
Possible adverse effects
Adverse effects are rare with megestrol. It may cause weight gain owing to increased appetite and food intake. Stop taking the drug and consult your doctor if a rash occurs.
Interactions
None known.
Over 60
No special problems.
Driving and hazardous work
No known problems.
Alcohol
No known problems.
Prolonged use
Long-term use of this drug may increase the risk of blood clots in the leg veins.
Monitoring
Periodic checks on blood pressure may be performed.
